目的 研究当归水提物多成分体内代谢动态变化过程，筛选当归的质控成分，寻找中药质量评价新方法。方法 采用肠系膜静脉和腹主动脉取血的方法，运用HPLC对比分析当归经肠代谢和肝代谢的化学成分特征谱，推断当归水提物中多成分的代谢变化过程。结果 分析的15种成分在消化液中均基本稳定，其中有4种成分可能被肠道代谢，7种成分被肝脏代谢。并发现1种新成分是肝代谢产物，7种新成分是肠代谢产物，但其中5种肠代谢产物经肝脏又被代谢转化，未能吸收入血。最终确定了当归水提物中的4种原型成分和3种肠肝代谢产物能吸收入血。结论 综合分析当归各成分的代谢轮廓，初步筛选出包括洋川芎内酯I在内的4种原型成分作为质控成分，建立了“质代关联”的中药质量评价方法。

Objective To study the dynamic processes of in vivo metabolism of multicomponent in the decoction of Angelicae Sinensis Radix (ASR), select the quality control components, look for a new quality evaluation method for Chinese materia medica (CMM). Methods The blood was taken from mesenteric vein and abdominal aorta. By analyzing HPLC fingerprints of intestinal metabolism and liver metabolism, we could infer multicomponent changes in the metabolic process of water extract from ASR. Results Totally 15 components were basically stable in the digestive juice, four of them may be metabolized by intestine, while seven of them were metabolized by liver. And we found one new component was the metabolite of liver, seven new components were the metabolites of intestine, but five of them were metabolized by liver and could not be absorbed into blood. Finally, we identified that four prototype components of water extract from ASR and three metabolites could be absorbed into blood. Conclusion Based on the multicomponent metabolic profiling of ASR, we initially select the four prototype components including senkyunolide I as the quality control component, and we finally establish a quality evaluation method for "correlation in quality and metabolism".

国家自然科学基金资助项目（81303217，81374027，81274042）；北京中医药大学校级课题（2015-JYB-XS070）