目的 对黄柏Phellodendri Cortex（黄皮树Phellodendron chinense的干燥树皮）的非生物碱部分进行化学成分研究。方法 采用732型阳离子交换树脂柱色谱、D101大孔吸附树脂柱色谱、正相硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱等方法进行分离纯化，并根据化合物的理化性质、波谱及光谱数据鉴定化合物的结构。结果 从黄柏70%乙醇提取物的非生物碱部分分离得到14个化合物，分别鉴定为（-）-3-O-阿魏酰奎宁酸甲酯（1）、（-）-4-O-阿魏酰奎宁酸甲酯（2）、（-）-绿原酸甲酯（3）、（-）-5-O-阿魏酰奎宁酸甲酯（4）、毛柳苷（5）、阿魏酸甲酯（6）、咖啡酸甲酯（7）、4-羟基苯乙醇（8）、3,4,5-三甲基苯酚-O-β-D-葡萄糖苷（9）、2-methoxy-4-（2-propenyl） phenyl-β-D-glucopyranoside（10）、tachinoside（11）、丁香酸甲酯（12）、（6S）-去氢催吐萝芙木醇（13）、（6R,7aR）-地芰普内酯（14）。结论 化合物9～14均为首次从该属植物中分离得到。

Objective To study the non-alkaloids from the 70% ethanolic extracts of Phellodendri Cortex. Methods A variety of 732 cation exchange resin chromatography, D101 macroporous adsorbent resin chromatography, silica gel chromatography, ODS column chromatography, Sephadex LH-20 chromatography, and preparative HPLC methods were used for the separation and purification of chemical composition. Their structures were established on the basis of physicochemical properties and spectral analysis. Results Fourteen compounds were identified as (-)-3-O-feruloylquinic acid methyl ester (1), (-)-4-O-feruloylquinic acid methyl ester (2), (-)-chlorogenic acid methyl ester (3), (-)-5-O-feruloylquinic acid methyl ester (4), salidroside (5), methyl ferulate (6), caffeic acid methyl ester (7), p-hydroxylbenzyl ethanol (8), 3, 4, 5-trimetoxyphenol-O-β-D-glucopy ranoside (9), 2-methoxy-4- (2-propenyl) phenyl β-D-glucopyranoside (10), tachinoside (11), methyl syringate (12), (6S)-dehydrovomifoliol (13), and (6R, 7aR)- epiloliolide (14). Conclusion Compounds 9-14 are isolated from the plants in this genus for the first time.

国家自然科学基金重点项目（81430095）