[关键词]
[摘要]
目的 研究杭白芷Angelica dahurica var. formosana醋酸乙酯部位的化学成分。方法 采用硅胶、HPLC等柱色谱方法进行分离纯化,通过质谱、核磁共振谱学数据鉴定化合物结构。结果 从杭白芷70%乙醇水提取物的醋酸乙酯部位分离鉴定了42个化合物,分别为欧前胡素(1)、珊瑚菜内酯(2)、佛手酚(3)、独活属醇(4)、镰叶芹二醇(5)、异欧前胡素(6)、白当归素(7)、补骨脂素(8)、香柑内酯(9)、异栓翅芹烯醇(10)、日本当归醇A(11)、白术内酰胺(12)、二氢欧山芹醇当归酸酯(13)、5-羟基-8-甲氧基补骨脂素(14)、(8E)-1,8-十七碳二烯-4,6-二炔-3,10-二醇(15)、栓翅芹烯醇(16)、白当归素乙醚(17)、异白当归脑(18)、伞形花内酯(19)、花椒毒酚(20)、欧芹酚甲醚(21)、别欧前胡素(22)、5-(2-乙酰氧基-3-羟基-3-甲基丁氧基)补骨脂素(23)、水合氧化前胡素(24)、氧化前胡素乙醚(25)、别异欧前胡素(26)、牧草栓翅芹酮(27)、氧化别欧前胡素(28)、异氧化前胡内酯(29)、腺嘌呤(30)、反式阿魏酸(31)、香草酸(32)、2-乙氧基-2-对羟基苯乙醇(33)、栓质花椒素(34)、异茴芹素(35)、花椒毒素(36)、尤劳帕替醇(37)、2,4-二羟基苯甲酸甲酯(38)、滨蒿内酯(39)、东印度缎木内酯醇(40)、印度榅桲素(41)、5-羟甲基糠醛(42)。结论 除化合物1、3、6、7、10、13、14、16、21、24和26外,其余化合物均为首次从杭白芷中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of ethyl acetate soluble parts in 70% ethanol aqueous extract from the roots of Angelica dahurica var. formosana. Methods The compounds were separated and purified by repeated column chromatography on silica gel and HPLC, and their structures were determined by spectroscopic data analyses of MS and NMR. Results Forty-two compounds were obtained and identified as imperatorin (1), phellopterin (2), bergaptol (3), heraclenol (4), falcarindiol (5), isoimperatorin (6), byakangelicin (7), psoralen (8), bergapten (9), isogosferol (10), japoangelol A (11), atractylenolactam (12), columbianadin (13), 5-hydroxy-8-methoxypsoralen (14), (8E)-1, 8-heptadecadiene-4, 6-diyne-3, 10-diol (15), pabulenol (16), byakangelicin ethoxide (17), isobyakangelicol (18), umbelliferone (19), xanthotoxol (20), osthole (21), alloimperatorin (22), 5-(2-acetoxy-3-hydroxy-3-methylbutoxy) psoralen (23), oxypeucedanin hydrate (24), oxypeucedanin ethanolate (25), alloisoimperatorin (26), pabularinone (27), oxyalloimperatorin (28), isooxypeucedanin (29), adenine (30), trans-ferulic acid (31), vanillic acid (32), 2-ethoxy-2-(4-hydroxyphenyl)-ethanol (33), suberosin (34), isopimpinellin (35), xanthotoxin (36), ulopterol (37), 2, 4-dihydroxybenzoic acid methylate (38), scoparone (39), swietenol (40), marmesin (41), and 5-hydroxymethylfurfural (42), respectively. Conclusion Except for the compounds 1, 3, 6, 7, 10, 13, 14, 16, 21, 24, and 26, other compounds were isolated from the roots of A. dahurica var. formosana for the first time.
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[基金项目]
“十二五”国家科技支撑专项(2012BAI29B02,2011BAI07B08);国家自然科学基金资助项目(81473321);北京市自然科学基金资助项目(7152086)