姜黄素是从姜黄根茎中提取的多酚类化合物,是姜黄的主要活性成分之一,具有抗炎、抗氧化和抗癌等多种生物学作用。在抗氧化过程中姜黄素能提供质子,通过调控Nrf2-ARE、核因子-κB(NF-κB)、NADPH/ROS、Notch、AMPK/eNOS和MAPK等多条信号转导通路,激活相关信号转导分子,调节相应的功能基因表达水平,增加或抑制多种蛋白的表达,诱导产生抗氧化酶,改善氧化应激,发挥抗氧化作用。

Curcumin is one of the polyphenolic compounds, which is the biological active ingredient of Curcuma longa. Studies indicate a beneficial role of curcumin in terms of anti-oxidant, anti-tumourgenic, and anti-inflammatory properties. And H-atom transfer is a preferred anti-oxidant mechanism of curcumin. Curcumin activates the Nrf2-ARE, NF-κB, NADPH oxidase/ROS, Notch, AMPK/eNOS, and MAPK signal transduction pathways, induces or inhibits signaling molecules and functional gene, modulates the protein expression, increases anti-oxidant enzyme activities, and counteracts oxidative stress.

院企合作项目:吸血水蛭人工养殖关键技术研究与开发(LM20160001)