[关键词]
[摘要]
目的 以介孔二氧化硅纳米粒(MSN)为载体制备姜黄素-介孔二氧化硅纳米粒固体分散体(Cur-MSN-SD)并研究其对姜黄素(Cur)溶出速率及溶解度的影响。方法 采用聚合法制备了MSN,并运用溶剂法制备Cur-MSN-SD。通过扫描电镜、氮气吸附实验、红外光谱分析、差示扫描量热法表征Cur-MSN-SD,随后比较了Cur与Cur-MSN-SD溶出速率及溶解度。结果 所制备的MSN平均孔径为2.737 nm,具有典型的介孔结构特征,Cur分散于孔道内。当Cur与MSN质量比为1:4时,药物累积溶出率和溶解度改善效果最佳。结论 以MSN为载体制备的Cur-MSN-SD能显著改善Cur累积溶出率和溶解度,为解决Cur的水不溶性提供了一种有效的方法。
[Key word]
[Abstract]
Objective Taking mesoporous silica nanoparticle (MSN) as carrier, to prepare curcumin (Cur)-MSN-solid dispersion (SD) for study on its effect on the dissolution rate and solubility of Cur. Methods MSN was prepared by condensation method and Cur-MSN-SD was obtained using solvent evaporation method. Then, Cur-MSN-SD was characterized with scanning electron microscope, nitrogen adsorption test, infrared spectrum analysis, and differential scanning calorimetry. Then the dissolution rate and solubility between Cur and Cur-MSN-SD were compared. Results The average pore diameter of prepared MSN was 2.737 nm, with the feature of typical mesoporous structure, and Cur was distributed in the channel. The cumulative dissolution rate and solubility of the drug were the best as the mass ratio of Cur to MSN was 1:4. Conclusion The Cur-MSN-SD prepared with the MSN as carrier could improve the cumulative dissolution rate and solubility of Cur, which provides an effective method for solving the water non-solubility of Cur.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81302729);西南民族大学中央高校基本科研业务费专项资金项目(2016NZYQN15)