目的 研究海南红树植物角果木Ceriops tagal二萜类化学成分。方法 利用HP20大孔树脂柱色谱和正、反相硅胶柱色谱以及高效液相色谱等手段进行分离制备,并根据化合物的理化性质和波谱数据鉴定化合物结构。结果 从角果木醋酸乙酯萃取部位中共分离得到11个dolabrane型二萜类化合物,分别鉴定为 (5S^*,8S^*,9S^*,10R^*)-13S^*,18-dihydroxy-15,16- dinordolabr-4(18)-ene-3-one(1)、(5S^*,8S^*,9S^*,10R^*,13S^*)-3,16-dihydroxydolabr-3-ene-2-one(2)、tagalsin S(3)、ent-5α,2,15- dioxodolabr-3-ene-3,16-diol(4)、ent-16-nor-5α,2-oxodolabr-3-ene-3-ol-15-oic acid(5)、tagalsin P(6)、ent-5α,3,15- dioxodolabr-1,4(18)-diene-2,16-diol(7)、ent-16-nor-3-oxodolabr-1,4(18)-diene-2-ol-15-oic acid(8)、tagalsin W(9)、tagalsin V(10)、tagalsin Q(11)。结论 化合物1和2为新化合物,分别命名为角果木二萜A和角果木二萜B。

Objective To investigate diterpenoids of Ceriops tagal, from Hainan mangrove. Methods Eleven dolabrane-type diterpenoids were obtained by HP20 macroporous resin, silica gel, and RP C₁₈ column chromatography and HPLC preparation. The structures of these compounds were elucidated on the basis of physicochemical properties and spectroscopic data. Results The eleven dolabranes were obtained from the ethyl acetate extraction from the aerial part of C. tagal. These compounds were identified as (5S^*,8S^*,9S^*,10R^*)-13S^*,18-dihydroxy-15,16-dinordolabr-4(18)-ene-3-one (1), (5S^*,8S^*,9S^*,10R^*,13S^*)-3,16-dihydroxydolabr-3-ene- 2-one (2), tagalsin S (3), ent-5α,2,15- dioxodolabr-3-ene-3,16-diol (4), ent-16-nor-5α,2-oxodolabr-3-ene-3-ol-15-oic acid (5), tagalsin P (6), ent-5α,3,15-dioxodolabr-1,4 (18)-diene-2,16-diol (7), ent-16-nor-3-oxodolabr-1,4(18)-diene-2-ol-15-oic acid (8), tagalsin W (9), tagalsin V (10), and tagalsin Q (11). Conclusion Compounds 1 and 2 are new compounds named as tagalditerpene A and tagalditerpene B.

国家自然科学基金资助项目(U1501221)