[关键词]
[摘要]
山楂Crataegus pinnatifida又名山里红,是一种在中国广泛分布的蔷薇科山楂属木本植物。山楂树(hawthorn tree)资源包括山楂浆果、山楂叶、山楂花、山楂树皮,富含黄酮类、三萜类、有机酸类、甾醇类及糖类等生物活性物质,均已被作为中药材应用于临床。目前国内外对山楂在临床防治糖尿病及其并发症方面进行了大量研究,发现山楂具有降血糖、调血脂、抗氧化应激、改善胰岛素抵抗、抗炎以及改善糖尿病并发的血管病变等作用。针对山楂树资源对2型糖尿病及其并发症的防治作用及其机制进行综述,为合理利用山楂资源及开发新型糖尿病治疗药物提供依据。
[Key word]
[Abstract]
Hawthorn, also known as dried Crataegus pinnatifida, is a kind of woody plants widely distributed in China. Hawthorn resources including berries, leaves, flowers, and barks, which enrich the bioactive substances, such as flavonoids, triterpenes, sterols, organic acid, sugar, and so on. A lot of studies have found the role of hawthorn for preventing and treating type 2 diabetes and its complications. Till now, hawthorn resources have been used as medicine in clinic. In order to take better advantage of hawthorn resources and explore new diabetic drugs, we review here the recent advances in study on the pharmacological effects of hawthorn resources, i.e. reducing blood glucose, lipid, insulin resistance, oxidant stress, inflammations, and relative vascular complications.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81501421,81370165);宁波市科技创新团队项目(2014B82002);宁波市自然科学基金项目(2015A610176,2013A610209,200701A6304004);宁波大学学科资助项目(F01223144302)