[关键词]
[摘要]
目的 研究尼泊尔酸模Rumex nepalensis根的化学成分。方法 采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱及半制备型高效液相色谱等方法进行分离纯化,并通过化合物的波谱数据鉴定其结构。结果 从尼泊尔酸模根的醋酸乙酯萃取物中分离鉴定了16个化合物,分别为阿魏酸(1)、7-羟基-5-甲氧基苯酞(2)、2-乙酰基-3,5-二羟基-苯乙酸甲酯(3)、苔色酸甲酯(4)、对羟基肉桂酸甲酯(5)、2-羟基-5-甲基苯乙酮(6)、丁香酸甲酯(7)、2,4-二羟基-6-甲基苯乙酮(8)、对羟基苯乙醇(9)、异香草醛(10)、迷人醇(11)、7-羟基-2,5-二甲基色原酮(12)、3-乙酰基-2-甲基-1,5-二羟基-2,3-环氧基-4-羰基-萘酮(13)、大黄素(14)、大黄酚(15)、大黄素甲醚(16)。结论 化合物12和13为首次从尼泊尔酸模中分离得到,1~11均为首次从酸模属植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents from the ethyl acetate extracts in the roots of Rumex nepalensis. Methods The compounds were isolated by using various chromatographic techniques, such as silica gel column, Sephadex LH-20 column, and semi-preparative HPLC. The structures of these compounds were determined by spectral data analyses. Results Sixteen compounds were obtained and identified as ferulic acid (1), 7-hydroxy-5-methoxyphthalide (2), methyl 2-acetyl-3,5- dihydroxyphenylacetate (3), methylorsellinate (4), methyl p-hydroxycinnamate (5), 1-(2-Hydroxy-5-Methyl-phenyl)-ethanon (6), methyl syringate (7), 1-(2,4-dihydroxy-6-methylphenyl)-ethanon (8), 4-hydroxy-benzeneethanol (9), isovanillin (10), fallacinol (11), 7-hydroxy-2-methyl-5-methylchromone (12), 3-acetyl-2-methyl-1,5-dihydroxy-2,3-epoxynaphthoquinol (13), emodin (14), chrysophanol (15), and physcion (16). Conclusion Compounds 12 and 13 are isolated from this plant for the first time, and compounds 1—11 are firstly isolated from the plants of Rumex L.
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[基金项目]
国家高技术研究发展计划(863计划)(2011AA100607);中央高校科研业务费(XDJK2014A008,2362015XK08)