目的 对羌活Notopterygium incisum的化学成分进行研究。方法 采用硅胶柱色谱、HPLC以及Sephadex LH-20凝胶柱色谱等方法进行分离纯化,并结合现代波谱学技术对分离得到的化合物进行结构鉴定。结果 从羌活的70%乙醇提取物中分离得到14个化合物,分别鉴定为7-羟基香豆素(1)、5,7-二甲氧基香豆素(2)、紫花前胡内酯(3)、佛手酚(4)、佛手柑内酯(5)、异虎耳草素(6)、比克白芷内酯(7)、(+)-顺式凯林内酯(8)、(-)-反式凯林内酯(9)、茴香酸对羟基苯乙酯(10)、5-甲氧基-8-羟基补骨脂内酯(11)、阿魏酸(12)、异欧前胡素(13)和异补骨脂素(14)。结论 化合物2 、7~9 和11 为首次从羌活属植物中分离得到。

Objective To investigate the chemical constituents of Notopterygium incisum. Methods The chemical constituents were isolated by silica gel column chromatography, HPLC, and Sephadex LH-20 column chromatography. Their structures were identified on the basis of spectral data analysis. Results Fourteen compounds were isolated and identified as 7-hydroxycoumarin (1), 5,7-dimethoxycoumarin (2), nodakenetin (3), bergaptol (4), bergapten (5), isopimpinellin (6), byakangelicin (7), (+)-cis-khellactone (8), (-)-trans-khellactone (9), p-hydroxypenehtyl anisate (10), 5-methoxy-8-hydroxypsoralen (11), ferulic acid (12), isoimperatorin (13), and isopsoralen (14). Conclusion Compounds 2, 7-9, and 11 are isolated from the plants of Notopterygium H. Boiss. for the first time.

科技部重大新药创制:现代中药创新集群与数字制药技术平台(2013ZX09402203)