[关键词]
[摘要]
目的 研究广西黄花三宝木Trigonostemon lutescens中二萜类成分。方法 用色谱分离法对黄花三宝木乙醇提取物进行分离纯化,根据理化性质和波谱信息鉴定化合物的结构。结果 从黄花三宝木的95%乙醇提取物中分离得到12个二萜类化合物,分别鉴定为trigoxyphin A(1)、3,16α-二羟基-贝壳杉烷(2)、3,16α-二羟基-对映贝壳杉烷(3)、10,16α-二羟基-异贝壳杉烷(4)、3,5,16α-三羟基-对映贝壳杉烷(5)、8α-羟基-3,4-开环海松烷-4,15(18)-二烯-3-酸(6)、8α-羟基-3,4-开环海松烷-4,15(8)-二烯-3-酸甲酯(7)、3,4-开环海松烷-4,8(9),15(18)-三烯-3-酸甲酯(8)、trigoflavidone A(9)、克罗烷-2,4,11-三烯-17-酸甲酯(10)、3α-羟基-贝壳杉烷-16-烯(11)、13α-羟基-16-烯-贝壳杉烷-18-酸甲酯(12)。结论 所有化合物均为首次从黄花三宝木中分离得到。
[Key word]
[Abstract]
Objective To study the daphnane diterpenoids of Trigonostemon lutescens form Guangxi province. Methods The ethanol extract of T. lutescens was separated and purified by column chromatography, and the structures of the compounds were identified by physicochemical properties and spectral data. Results Twelve daphnane diterpenoids were separated and identified form T. lutescens as trigoxyphin A(1), 3, 16α-dihydroxy-kaurane(2), entkaurane-3, 16α-diol(3), 10, 16α-dihydroxy-isokaurane(4), entkaurane-3, 5, 16α-triol(5), 8α-hydroxy-3, 4-secopimara-4, 15(18)-diene-3-oic acid(6), 8α-hydroxy-3, 4-secopimara-4, 15(18)-diene-3-oate(7), 3, 4-secopimara-4, 8(9), 15(18)-triene-3-acid-methyl ester(8), trigoflavidone A(9), clerodane-2, 4, 11-triene-17-acid methyl ester(10), 3α-dihydroxy-kaurane-16-ene(11), and 13α-dihydroxy-kaurane-16-ene-18-acid methyl ester(12). Conclusion All these daphnane diterpenoids are first separated and identified form T. lutescens.
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[基金项目]
广西大学科研基金项目(XBZ111472);南宁市科学研究与技术开发项目(20133009)