组织因子(tissue factor,TF)亦称为组织凝血活酶,是生理性止、凝血过程及多种病理性血栓形成的启动因子,在动脉粥样硬化、系统性炎症、心绞痛、弥散性血管内凝血、肿瘤的血管发生与转移等多种疾病的形成中发挥重要作用。寻找以TF 为靶点的抗凝、抗血栓药物具有重要的理论和现实意义,概述了近年来对血栓形成中TF 表达具有调节作用的中药有效成分的研究进展。

Tissue factor (TF), also called tissue thromboplastin, is the principal initiator of physiological blood coagulation and hemostasis and pathological thrombosis, and plays an important role in the formation of various diseases in atherosclerosis, systemic inflammation, angor pectoris, disseminated intravascular coagulation, and tumor angiogenesis and metastasis. Looking for the targets to TF anticoagulant, antithrombotic drug has important theoretical and realistic significance. This summary outlines the research progress of the active components in Chinese materia medica with modulating effects on expression of tissue factor in thrombosis in recent years.

广西省自然科学基金资助项目(2013GXNSFBA019145);广西科技基础条件平台建设项目(10-046-04,13-051-06);广西中医药大学课题(P2012019)