目的 对茄科酸浆属植物毛酸浆Physalis pubescens果实的化学成分进行研究。方法 利用多种色谱分离技术进行分离纯化,根据其理化性质和波谱数据鉴定化合物结构。结果 从毛酸浆果实80%乙醇提取物中分离并鉴定了9个化合物,分别为5-羟甲基糠醛(1)、咖啡酸乙酯(2)、β-谷甾醇(3)、反式对羟基肉桂酸乙酯(4)、槲皮素-3,5,7三甲氧基-3'-O-β-D-吡喃葡萄糖苷(5)、槲皮素-3-O-(6'-O-反式对香豆酰基)-β-D-吡喃葡萄糖苷(6)、山柰酚-3-O-β-D-芸香糖苷(7)、橄榄苦苷(8)、4,4'-二羟基-2'-甲氧基查耳酮(9)。结论 化合物4~9为首次从茄科酸浆属植物中分离得到,化合物1为首次从该植物中分离得到。

Objective To investigate the chemical constituents from the berries of Physalis pubescens.Methods The constituents from the 80% ethanol extract of berries of P.pubescens were separated and purified by all several chromatographic technologies.The isolated compounds' structures were elucidated by physicochemical properties and spectral data analysis.Results Nine compounds were isolated and purified.They were identified as 5-hydroxymethylfurfural(1), ethyl caffeate(2), β-sitosterol(3), trans-p-hydroxyl ethyl cinnamate(4), quercetin 3, 5, 7-trimethyl ether 3'-O-β-D-glucopyranoside(5), quercetin-3-O-(6'-O-trans-p-coumaroyl)-β-Dglucopyranoside(6), kaempferol-3-O-β-D-rutinoside(7), oleuropein(8), and 4, 4'-diol-2'-methoxychalcone(9).Conclusion Compounds 4-9 are obtained from the plants of genus Physalis L.for the first time, and compound 1 is isolated from P.pubescens for the first time.

吉林省医药产业发展专项资金项目(20130727066YY);长春市重大科技攻关计划项目(14KG061)