[关键词]
[摘要]
目的 研究苏木Caesalpinia sappan的化学成分。方法 利用正相硅胶柱色谱、Sephadex LH-20、反相硅胶柱色谱及反相制备液相色谱等手段进行分离纯化,并通过1H-NMR、13C-NMR等波谱技术进行结构鉴定。结果 从苏木醋酸乙酯提取物中分离得到12个化合物,分别鉴定为原苏木素A(1)、3,7-二羟基色原酮(2)、7,3',4'-trihydroxy-3-benzyl-2H-chromene(3)、bonducellin(4)、3'-去氧苏木醇(5)、3'-去氧-4-甲氧基表苏木醇(6)、3-去氧苏木查耳酮(7)、3,8,9-thihydroxy-6H-benzo[c]chromen-6-one(8)、3,9-dihydroxy-8-methoxy-dibenzo [b,d] pyran-6-one(9)、(-)-丁香树脂酚(10)、邻苯二甲酸二丁酯(11)、正二十一烷醇(12)。结论 化合物9、11、12为首次从云实属中分离得到,化合物4为首次从苏木植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents in Sappan Lignum (the core material of Caesalpinia sappan). Methods The chemical constituents of Sappan Lignum were isolated by different column chromatographic techniques, including silica gel and Sephadex LH-20 columns. The structures of these compounds were identified by a comprehensive analysis on the spectroscopic data. Results Fifteen compounds were isolated from the EtOAc extract of Sappan Lignum. The compounds were identified as protosappanin A (1), 3,7-dihydroxychroman-4-one (2), 7,3',4'-trihydroxy-3-benzyl-2H-chromene (3), bonducellin (4), 3'-deoxysappanol (5), 3'-deoxy-4-O-methylepisappanol (6), 3-deoxysappanchalcone (7), 3,8,9-thihydroxy-6H-benzo[c] chromen-6-one (8), 3,9-dihydroxy-8-methoxydibenzo [b, d] pyran-6-one (9), (-)-syringaresinol (10), dibutyl phthalate (11), β-sitosterol (12), β-daucosterol (13), stigmasterol (14), and 1-heneicosanol (15). Conclusion Compounds 9, 11, and 12 are first isolated from the plants of Caesalpinia Linn. and compound 4 is first isolated from this plant.
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[基金项目]
国家“十一五重大新药创制”重大专项基金(2011ZX09307-002-02);湖南省重点实验室重点课题(XNZW14K03)