[关键词]
[摘要]
目的 研究合子草Actinostemma lobatum全草的化学成分。方法 综合应用正、反相硅胶,Sephadex LH-20以及HPLC等现代色谱技术进行分离纯化,根据化合物的理化性质和波谱学性质鉴定化合物的结构。结果 从合子草全草的75%乙醇提取物中分离得到12个化合物,分别鉴定为lobatoside B(1)、土贝母皂苷乙(2)、土贝母皂苷戊(3)、没食子酸(4)、没食子酸甲酯(5)、原儿茶酸(6)、原儿茶酸甲酯(7)、对羟基苯乙酮(8)、对羟基苯甲酸(9)、对羟基苯甲醛(10)、5-羟甲基-2-呋喃甲醛(11)、5-羟甲基-2-呋喃乙酮(12)。结论 化合物2、5~12为首次从该属植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents from the whole plant of Actinostemma lobatum. Methods The chemical constituents were isolated from the 75% alcohol extract of A. lobatum by silica column chromatography, C18, Sephadex LH-20 columns, and RP-HPLC. Their chemical structures were elucidated on the basis of physicochemical and spectral properties, 1H-NMR, and 13C-NMR. Results Twelve compounds were isolated and identified as lobatoside B (1), tubeimoside II (2), tubeimoside V (3), gallic acid (4), methyl gallate (5), protocatechuic acid (6), protocatechuic acid methyl ester (7), 4-hydroxyacetophenone (8), p-hydroxybenzoic acid (9), p-hydroxybenzaldehyde (10), 5-(hydroxymethyl)-2-furaldehyde (11), and 1-[5-(hydroxymethyl) furan-2-yl] ethanone (12). Conclusion Compounds 2 and 5-12 are isolated from the plants in Actinostemma Griff. for the first time.
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[基金项目]
江西省科技厅青年科学基金(20142BAB215023)