[关键词]
[摘要]
目的 对栀子Gardenia jasminoides花进行化学成分研究。方法 采用大孔吸附树脂、硅胶柱色谱和高效液相色谱等方法进行分离纯化,并通过理化常数和各种波谱学技术鉴定所分离化合物的化学结构。结果 共分离并鉴定了10个化合物,分别为山柰酚3-O-β-D-吡喃葡萄糖苷(1)、山柰酚3-O-β-D-吡喃半乳糖苷(2)、山柰酚3-O-洋槐糖苷(3)、山柰酚3-O-芸香糖苷(4)、(6S,9S)-长寿花糖苷(5)、反式对羟基肉桂酸甲酯(6)、香草醛(7)、咖啡酸(8)、原儿茶酸(9)和β-谷甾醇(10);其中,化合物1~4为4个黄酮苷类化合物,化合物5为单萜苷类化合物,化合物6~9为3个酚酸类化合物。结论 化合物2、3、5~7为首次从栀子属植物中分离得到,化合物1、4、8和9为首次从栀子的干燥花中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the flowers of Gardenia jasminoides. Methods The compounds were isolated by extensive chromatographic methods, including macroporous adsorption resin, silica gel column chromatography, and HPLC method. Their structures were elucidated on the basis of physiochemical properities and spectroscopic data. Results Ten compounds were obtained and identified as kaempferol 3-O-β-D-glucopyranoside (1), kaempferol 3-O-β-D-galactopyranoside (2), kaempferol 3-O-robinobioside (3), kaempferol 3-O-rutinoside (4), corchoionoside C (5), (E)-p-hydroxycinnamic acid methyl ester (6), vanillin (7), caffeic acid (8), protocatechuic acid (9), and β-sitosterol (10). Among them, compounds 1-4 belong to flavonoid glucosides. Conclusion Compounds 2, 3, and 5-7 are first isolated from the plants of Gardenia Ellis and compounds 1, 4, 8 and 9 are first isolated from the flowers of G. jasminoides.
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[基金项目]
国家“重大新药创制”科技重大专项(2012ZX09304007)