[关键词]
[摘要]
心律失常是心血管疾病中一类重要的疾病,严重威胁着人类的健康。抗心律失常药物多为离子通道阻滞剂,存在效率低的特点,并伴随严重的副作用。因此,对药物作用机制的深入研究并发展新的治疗策略,成为抗心律失常药物研究的新热点。后基因组学加速了对基因突变、基因多态性、基因表达量变化及表观遗传学改变的理解和认识,它们在心律失常的发生和发展过程中同样起着重要作用。而传统中药在治疗心律失常方面因其疗效显著、副作用少等优势,受到越来越多的关注。就目前与心律失常相关的基因及其对应疾病进行概述,并从中药复方及其有效成分调节异常表达基因的角度,对现有中药抗心律失常的可能靶点进行总结。以期为中药抗心律失常药理学研究提供借鉴。
[Key word]
[Abstract]
Cardiac arrhythmia is one of the most common types of cardiovascular diseases that seriously threaten human health. Presently, ion channel blockers are the main options for the treatment of cardiac arrhythmia. However, limited effectiveness and significant adverse effects severely tarnish their clinical application. Therefore, new anti-arrhythmic strategies and agents are urgently in demand. Post-genome era has paved the way for the accelerated discovery of novel gene mutations, gene polymorphisms and the change of gene expression and epigenetics that are attributable to cardiac arrhythmia. Chinese materia medica(CMM), known for its greater efficacy and less side effects, is a promising resource for novel anti-arrhythmic agents. This review summarizes cardiac arrhythmia-related genes and their pathological mechanisms. CMM formulae and derived compounds as potential multi-targeting anti-cardiac arrhythmia drugs are also discussed.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81274128);科技部国家国际合作专项(2013DFA31620)