[关键词]
[摘要]
中药骨架缓释制剂成分复杂,其多组分、多靶点的药效学特征要求各组分达到同步缓释,但药物组分之间理化性质差异常常影响其释放的同步性。通过查阅相关文献,对亲水凝胶骨架材料、不溶性骨架材料、溶蚀性骨架材料以及混合骨架材料对多组分中药的同步缓释的影响进行概述,为中药骨架缓释制剂进一步的研究与发展提供参考。
[Key word]
[Abstract]
Components of matrix sustained-release preparation of Chinese materia medica (CMM) are complex, the multi-component and multi-target features of the pharmacological require the synchronous release of all the components, which are also influenced by the difference of their physicochemical properties. The article summarizes the effect of the multi-component on the synchronous release of CMM from hydrophilic matrix materials, infusibility matrix materials, bioerodible matrix materils, and mixed matrix materials by reviewing the related literatures, in order to provide the reference for the further research and development of multicomponent skeleton sustained-release preparation.
[中图分类号]
[基金项目]
福建省自然科学基金资助项目--基于微孔渗透泵的中药多组分同步缓释技术研究(2015J01491)