[关键词]
[摘要]
目的 研究不同工艺对中药牡丹皮和肉桂配方颗粒中挥发性成分量的影响。方法 通过HPLC法测定不同制备工艺制得的牡丹皮配方颗粒中丹皮酚的量及肉桂配方颗粒中桂皮醛的量,对其工艺进行比较研究。结果 常规工艺制得的配方颗粒中丹皮酚和桂皮醛的量明显低于先提取挥发油,药渣提取物干燥后,再将挥发油直接喷洒或环糊精包合后加入制得的配方颗粒。结论 含挥发性成分中药牡丹皮和肉桂配方颗粒的最佳工艺为先提取挥发性成分,剩余药渣进行煎煮,然后对挥发性成分进行包合,制粒时再将其加入。
[Key word]
[Abstract]
Objective To study the influence on the volatile components of Chinese materia medica (CMM) Moutan Cortex and Cinnamomi Cortex formula granules produced by different preparative processes. Methods The different preparative processes were compared by determining the content of paeonol in Moutan Cortex formula granule and cinnamaldehyde in Cinnammi Cortex formula granule by HPLC. Results The contents of paeonol in Moutan Cortex formula granule and cinnamaldehyde in Cinnamomi Cortex formula granule produced by conventional process were significantly lower than those by the other processes, which was carried out as follows: extracting the volatile oil firstly, then drying the herb residue extract, adding the volatile oil by spaying directly or cyclodextrin inclusion finally. Conclusion The best process of CMM Moutan Cortex and Cinnamomi Cortex formula granules containing volatile components was as follows: extracting the volatile components firstly, then decocting the residues, and the volatile components was enclosed before adding in the granulation.
[中图分类号]
[基金项目]
天津市科技支撑计划重点项目(生物医药领域)--天津市配方颗粒质量标准研究(12ZCZDSY01000)