目的 对大株红景天Rhodiolawallichiana var. cholaensis根茎进行化学成分研究。方法 采用反复DAC柱色谱、Sephadex LH-20凝胶柱色谱及HPLC等色谱手段进行分离纯化,并采用有机波谱学等手段对化合物进行结构鉴定。结果 从大株红景天水提取物中分离得到15个化合物,分别鉴定为没食子酸(1)、丁香酸(2)、酪醇(3)、红景天苷(4)、3,4-二羟基苯甲酸(5)、对羟基苯甲酸(6)、对羟基苯乙酸(7)、对羟基苯丙烯酸(8)、对羟基苯丙烯酸4-O-β-D-葡萄糖苷(9)、苯甲醇-O-β-D-吡喃葡萄糖苷(10)、云杉苷(11)、二氢松柏苷(12)、岩白菜素(13)、rhodiocyanoside A(14)、5-羟甲基糠醛(15)。结论 化合物7、15为首次从红景天属植物中分离得到,化合物5～6、8～12、14为首次从大株红景天中分离得到。

Objective To investigate the chemical constituents from the water extract of Rhodiola wallichiana. Methods The chemical constituents were isolated by repeated dynamic axial compression chromatography, Sephadex LH-20 column chromatography, and prep-HPLC, and their structures were identified by the basis of spectral data analysis. Results Eleven compounds were isolated from the water extract and identified to be gallic acid (1), syringic acid (2), tyrosol (3), salidroside (4), 3,4- dihydroxybenzoic acid (5), 4-hydroxybenzoic acid (6), 4-hydroxyphenylacetic acid (7), p-coumaric acid (8), p-coumaric acid-4-O-β-D- glucopyranoside (9), benzyl-O-β-D-glucopyranodide (10), piceoside (11), dihydroconiferin (12), bergeninum (13), rhodiocyanoside A (14), and 5-hydroxymethylfurfural (15). Conclusion Compounds 7 and 15 are isolated from the plants of Rhodiola L. for the first time, and compounds 5—6, 8—12, and 14 are obtained from R. wallichiana for the first time.

科技部重大新药创制:现代中药创新集群与数字制药技术平台(2013ZX09402203)