[关键词]
[摘要]
目的 采用聚砜材质中空纤维超滤膜精制山茱萸水提液,考察方法的适用性,并进行膜超滤过程优化设计。方法 采用截留相对分子质量分别为5×104、1×104、6×103的中空纤维膜对山茱萸水提液进行超滤,以超滤前后山茱萸水提液中莫诺苷透过率、马钱苷透过率和共性高分子(果胶、鞣质、蛋白质、淀粉)截留率为指标,优选最佳截留相对分子质量的超滤膜;进而采用响应面法优选超滤过程的最佳工艺参数。结果 截留相对分子质量为1×104的中空纤维超滤膜有较好的分离效果;超滤最佳参数为药液温度50 ℃,药液质量浓度为0.13 g/mL,错流压差值为0.1 MPa。结论 中空纤维膜精制药液时选择合适孔径的膜及最佳的超滤条件能有效提高生产效率。
[Key word]
[Abstract]
Objective To explore the possibility for the application of ultrafiltration technology using polysulfone (PS) hollow fiber membrane to purlfy the water-extraction of Corni Fructus and optimize the preparation procedure. Methods The PS membrane of different aperture 5 ×104, 1 ×104, and 6 ×103 were studied on the applicability with water-extraction of Corni Fructus. The proper molecular weight retention was optimized with the removal of liquid impurities and the transformation. Taking the ratios of loganin transmittance and common polymers (pectin, tannin, protein, and starch) retention as indexes, the proper ultrafiltration condition was optimized by response surface method. Results The PS membrane with interception molecular weight of 1 ×104 had better separation efficiency and the preferred operation parameters were 0.1 MPa of pressure, 50 ℃ of liquid temperature, and solution concentration of 0.13 g/mL. Conclusion The preferred aperture of PS membrane and the operation conditions are feasible for the purification of water-extraction of Corni Fructus, which can improve the production efficiency.
[中图分类号]
[基金项目]
陕西省科技资源开放共享平台项目(2015FWPT-01);陕西省重点科技创新团队(2012KTC-20)