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[摘要]
目的 考察新工艺金芪降糖片对2型糖尿病大鼠的降血糖作用及其对2型糖尿病大鼠血脂的影响.方法 采用高脂饲料合并链脲佐菌素(STZ)尾iv制备大鼠2型糖尿病模型,造模后给药4周,测定大鼠空腹血糖、糖化血红蛋白、血清胰岛素、胰岛素抵抗指数、糖耐量指标,观察新工艺金芪降糖片对2型糖尿病大鼠的降血糖作用.测定血清胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C),观察新工艺金芪降糖片对2型糖尿病大鼠血脂的调节作用.结果 新工艺金芪降糖片在改善空腹血糖及糖耐量、糖化血红蛋白、胰岛素抵抗等方面均有明显效果.新工艺金芪降糖片能明显改善2型糖尿病大鼠TC和HDL-C水平.结论 新工艺金芪降糖片能有效改善2型糖尿病大鼠胰岛素抵抗,同时金芪降糖片兼具调血脂作用.
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[Abstract]
Objective To evaluate the effect of Jinqijiangtang Tablet prepared by new technology on blood glucose and lipids in rats with type 2 diabetes. Methods Type 2 diabetic rat model was established by high fat diet combined with STZ injection. Metformin was used for a positive drug in the present study. Fasting blood glucose, glycosylated serum protein, serum insulin, and insulin resistance index were determined to evaluate the hypoglycemic effect of Jinqijiangtang Tablet prepared by new technology. And serum triglyceride, cholesterol, high density and low density lipoprotein were observed to evaluate the lipid-lowering effect of Jinqijiangtang Tablet prepared by new technology. Results Jinqijiangtang Tablet prepared by new technology and metformin both could reduce the fasting blood glucose and glycosylated serum protein, and improve glucose tolerance and insulin resistance. Jinqijiangtang Tablet could reduce the levels of cholesterol and HDL.Conclusion Jinqijiangtang Tablet prepared by new technology can effectively improve insulin resistance, and it has a lipid-lowering effect.
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