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[摘要]
目的 研究鸭脚木Schefflera octophylla的化学成分.方法 采用硅胶、Sephadex LH-20和半制备HPLC等柱色谱分离手段进行分离纯化,根据理化性质和波谱数据鉴定其结构.结果 从鸭脚木中分离得到11个化合物,分别鉴定为2α,3β,23α-三羟基乌索-12-烯-28-酸-28-O-β-D-吡喃葡萄糖酯(1)、3α-羟基乌索-12-烯-23,28-二酸-28-O-α-L-鼠李糖 (1→4)-β-D-吡喃葡萄糖 (1→6)-β-D-吡喃葡萄糖酯(2)、积雪草苷(3)、葵醇(4)、十八烷醇(5)、二十四烷酸(6)、二十八烷酸(7)、十六烷酸(8)、异香草醛(9)、香草醛(10)、2-羟基-4-正辛氧基二苯甲酮(11).结论 化合物1为首次从鹅掌柴属植物中分离得到,4~11为首次从该植物中分离得到.
[Key word]
[Abstract]
Objective To study the chemical constituents from the roots of Schefflera octophylla.Methods The constituents were isolated and purified by repeated column chromatography on silica, Sephadex LH-20 gel, and HPLC. Their structures were elucidated by spectral analysis. Results Eleven compounds were isolated and identified as 2α,3β,23α-trihydroxy-urs-12-ene-28-oic acid-28-O-β-D-glucopyranoside (1), 3α-hydroxy-urs-12-ene-23,28-dioic acid 28-O-α-L-rhamnopyranosy1 (1→4)-β-D-glucopyranosyl (1→6)-β-D-glucopyranoside (2), asiaticoside (3), decanol (4), octadecanol (5), lignoceric acid (6), octacosanoic acid (7), hexadecanoic acid (8), isovanillin (9), vanillin (10), and 2-hydroxy-4-(octyloxy) benzophenone (11). Conclusion Compound 1 is isolated from the plants of Schefflera J. R. G. Forst. for the first time and compounds 4-11 are obtained from this plant for the first time.
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[基金项目]
广州市科技厅资助项目(12A062131631)