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[摘要]
目的 研究大花金挖耳Carpesium macrocephalum全草的化学成分。方法 采用硅胶、ODS、Sephadex LH-20等色谱方法进行分离纯化,根据理化性质、波谱数据以及X-射线单晶衍射方法鉴定化合物的结构。结果 从大花金挖耳丙酮提取物中分离得到5个百里香酚类单萜,分别鉴定为 (Z)-10-异丁酰氧基-9-氯-8,9-二羟基百里香酚(1)、9-异丁酰氧基-7,8-环氧-百里香酚异丁酸酯(2)、8-羟基-9-异丁酰氧基-10(2)-甲基丁酰氧基百里香酚(3)、8,10-二羟基-9-异丁酰氧基百里香酚(4)、10-异丁酰氧基-8,9-二羟基百里香酚(5)。结论 化合物1为新化合物,命名为大花金挖耳素;化合物2~5为首次从该属植物中分离得到。
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[Abstract]
Objective To investigate the chemical constituents from the whole plants of Carpesium macrocephalum. Methods Its constituents were isolated and purified by means of silica gel, ODS, and Sephadex LH-20 column chromatography. Their structures were elucidated on the basis of chemical evidences, spectroscopic methods, and X-ray data. Results Five thymol monoterpenoids were isolated from the acetone extract in the whole plants of C. macrocephalum and identified as (Z)-10-isobutyryloxy-9-chloro-8,9-dihydrothymol (1), 9-isobutyryloxy-7,8-epoxythymol isobutyrate (2), 8-hydroxy-9-isobutyryloxy-10(2)-methylbutyrylthymol (3), 8,10-dihydroxy-9-isobutyryloxythymol (4), and 10-isobutyryloxy-8,9-dihydrothymol (5), respectively. Conclusion Compound 1 is a new chlorinated thymol monoterpenoid named carpemacrom. Compounds 2—5 are isolated from the plants of Carpesium L. for the first time.
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[基金项目]
国家自然科学基金资助项目(81102335)