[关键词]
[摘要]
冠心病是一种由多种因素引发的复杂慢性疾病,是世界上死亡率最高的疾病之一。目前广泛应用于冠心病治疗的单靶点药物疗法已经不能满足疾病日益复杂的治疗需求,而传统中医药在治疗复杂疾病中疗效显著。通脉养心方是国医大师阮士怡教授在“炙甘草汤”基础上加以研究改进得来的,常用于治疗心血管类疾病。通脉养心方中单味药的研究如地黄、甘草等已经有了一定进展,但复方的整体研究依然进度缓慢。通脉养心方生物分子机制尚未清楚致使其在临床应用时存在一定风险。网络药理学可以从单味药和有效成分的角度去模拟通脉养心方的复合作用,即通过文本挖掘、数据库挖掘等方法,结合中医药理论构建成分-靶点网络、冠心病-通路靶点网络以及冠心病-证候网络,最后经过整合分析建立冠心病-证候-靶点-成分的总网络,为阐释通脉养心方的作用机制提供研究思路。
[Key word]
[Abstract]
Coronary artery disease (CAD) is a complex, multifactorial, chronic disease and one of the most dangerous diseases to human health due to its high mortality. The single target drug therapy is widely used in the treatment of CAD, but it could not meet the demand of today's treatment of complex disease. However, traditional Chinese medicine (TCM) has a good effect in treating complex disease. Tongmai Yangxin Prescription, based on “Zhigancao Decoction”, is used to cure cardiovascular disease. The formulae is developed by Professor Ruan Shi-yi who won the title of “Guo Yi Da Shi (master of national medicine)”. The studies on the single herb which consists in Tongmai Yangxin Prescription, such as Rehmanniae Radix and Glycyrrhizae Radix, have been made considerable progress. But systematic research of Tongmai Yangxin Prescription is still unavailable. There is a certain risk when we use Tongmai Yangxin Prescription in clinic, as the molecular basis of the formulae is unclear. The approach of network pharmacology is to set up a model of the compound action of Tongmai Yangxin Prescription. Meanwhile the model is based on the experimental data from single herb or active ingredients. Then, drug-target network, CAD-pathway network, and CAD-symptom network could be built to explain the functional mechanism through the method of literature mining and data mining, combining the theory of TCM.
[中图分类号]
[基金项目]
国家重点基础研究发展计划(“973”)项目(2014CB542902);国家自然科学基金资助项目(81403198)