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[摘要]
目的 对贡山八角Illicium wardii种子的化学成分进行研究。方法 采用桂胶色谱柱、Sephadex LH-20色谱柱、MCI色谱柱等方法进行分离纯化,根据化合物的理化性质和波谱数据鉴定其结构。结果 从贡山八角种子的95%乙醇提取物中分离得到11个倍半萜类化合物,分别鉴定为八角醇C(1)、7,8-epoxy-1(12)-caryophyllene-9β-ol(2)、merrilliortholactone(3)、2α-羟基新莽草毒素(4)、2,6-dihydroxyhumlan-9(E)-3(12),7(13),9-trien(5)、莽草毒素(6)、伪大八角素(7)、8α-hydroxy-10-deoxycyclomerrillianolide(8)、2α-羟基莽草毒素(9)、rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo-[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid(10)、菜豆酸(11)。结论 化合物1为新化合物,命名为八角醇C;其他化合物均为首次从该植物中分离得到。
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[Abstract]
Objective To investigate the chemical constituents from the seeds of Illicium wardii. Methods The chemical constituents were separated and purified by silica gel, Sephadex LH-20, MCI, etc. Results Eleven sesquiterpenoids were isolated from the 95% ethanol extract in the seeds of I. wardii. Their structures were elucidated as wardinol C (1), 7,8-epoxy-1(12)-caryophyllene-9β-ol (2), merrilliortholactone (3), 2α-hydroxyneoanisatin (4), 2,6-dihydroxyhumlan-9(E)-3(12),7(13),9-trien (5), anisatin (6), pseudomajucin (7), 8α-hydroxy-10-deoxycyclomerrillianolide (8), 2α-hydroxyanisatin (9), rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo-[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid (10), and phaseic acid (11). Conclusion Compound 1 is a new one, and the other compounds are isolated from this species for the first time.
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