人参皂苷及其衍生物已被证明具有显著的抗结肠癌作用。它们可通过抑制癌细胞增殖、减少癌细胞侵袭和转移、影响细胞周期、诱导癌细胞自噬并促细胞凋亡等方面发挥抑癌功效。近年来研究发现人参皂苷及其衍生物能协同增强抗结肠癌药物的疗效。对近10余年人参皂苷及其衍生物抗结肠癌的作用机制研究的文献进行查阅、分析和综述, 为从人参皂苷及衍生物中发现和研发靶向抗结肠癌新药提供科学参考。

Ginsenosides and their derivatives have been shown significant anti-colorectal cancer effect. They exert anti-colorectal cancer effects via inhibiting cancer cell proliferation and migration, blocking cell cycle progression, and inducing cell autophagy and apoptosis. Recently some active studies demonstrated that ginsenosides and their derivatives exhibited a synergistic anti-colorectal cancer effect with the drug. In this study, we summarized the progress in the research of ginsenosides and their derivatives in the treatment of colorectal cancer as well as analyzed their mechanisms, to provide the basis for the discovery and development of targeting anti-colorectal cancer drugs.

国家自然科学基金资助项目(81273389)