目的 研究虎杖Polygonum cuspidatum花的化学成分。方法 利用溶剂提取、硅胶柱色谱和Sephadex LH-20反复进行分离纯化, 根据波谱数据和理化性质鉴定化合物结构。结果 从虎杖花甲醇提取物的乙醚、甲醇萃取部分分离得到16个化合物, 分别鉴定为β-谷甾醇(1)、芦荟大黄素(2)、大黄素甲醚(3)、大黄素(4)、胡萝卜苷(5)、大黄酚(6)、槲皮素(7)、山柰酚(8)、蒽醌苷B(9)、大黄酸(10)、芹菜素(11)、橙皮素(12)、4-羟基苯乙酮(13)、芦丁(14)、蔗糖(15)、染料木素(16)。结论 化合物2、8、12、13、15、16为首次从虎杖花中分离得到。

Objective To investigate the chemical constituents in the flowers of Polygonum cuspidatum. Methods The components were separated by means of solvent extraction, repeated chromatography with silica and Sephadex LH-20 column. The structures were determined by spectral analysis and physicochemical properties. Results Sixteen compounds were isolated from the ethyl ether extract and methanol extract from the flowers of P. cuspidatum and identified as β-sitosterol (1), aloe-emodin (2), physcion (3), emodin (4), daucosterol (5), chrysophanol (6), luteolin (7), kaempferol (8), anthraglycoside B (9), rhein (10), apigenin (11), hesperetin (12), 4-hydroxyacetophenone (13), rutin (14), sucrose (15), and genistein (16). Conclusion Compounds 2, 8, 12, 13, 15, and 16 are obtained from the flowers of P. cuspidatum for the first time.

国家自然科学基金资助项目(31200261);山东省自然科学基金项目(ZR2012CQ029)