[关键词]
[摘要]
钉螺(oncomelania)是日本血吸虫Schistosoma japonicum的唯一中间寄主,是血吸虫病传播过程中不可缺少的环节。目前用于杀灭钉螺的化学药物存在生产成本高、严重污染环境、钉螺耐药性和对非靶体生物的毒性等诸多问题,这使人们将研究兴趣转向从植物中寻找天然灭螺药物。从结构类型、作用机制和构效关系等方面入手,对具有杀灭钉螺活性的植物源天然产物进行归纳总结,以期为新型植物源灭螺剂的开发提供参考。
[Key word]
[Abstract]
Oncomelania is the only intermediate host of Schistosoma japonicum as well as an indispensable part of schistosomiasis transmission. Now synthetic molluscicides have a lot of problems, such as high cost of production, chemical pollution, drug resistance, and toxicity to non-target body, which makes people's interest turn to plants and plant-derived compounds. This paper describes the current existence of chemical snail control methods and biological snail control methods on the view of chemical construction, mechanism of action, and structure-activity relationships of natural extracts with molluscicidal activity, in order to provide the basis for the development of the new plant molluscacide.
[中图分类号]
[基金项目]
国家“十二五”科技支撑项目(2011BAC13B04);国家自然科学基金资助项目(31260082)