[关键词]
[摘要]
目的 研究微粉化对蒸附片粉体学性质的影响, 为其制剂及质量控制提供依据。方法 采用超微粉碎机制备3种不同粉碎时间的蒸附片粉末, 检测其粒径分布、比表面积与孔隙度、流动性、微观结构、红外光谱、吸湿性及溶出速率等性质, 再对比进行综合分析。结果 随着粉碎时间的增加, 中粉、微粉I与微粉II的粒径逐渐减小, 形态及结构趋于均匀化, 但粒子易黏附聚集;同时比表面积与孔隙度增大;压缩度增大, 休止角增大;红外光谱无明显变化;吸湿性无显著差异;溶出速率加快。结论 综合蒸附片粉体学特征及溶出速率, 蒸附片入丸散剂粉末超微粉碎时间宜控制在25 min左右, 粒径d0.9宜在100.46 μm左右。
[Key word]
[Abstract]
Objective To study the effect of ultrafine grinding on the micromeritic properties of Zhengfupian (steamed pieces of Aconiti Lateralis Radix Praeparata) and provide the basis for its preparation and quality control. Methods Three kinds of Zhengfupian powders were prepared by ultrafine grinding mill. Their micromeritic properties, including size distribution, surface area and porosity, flowability, scanning electronic microscope, infrared spectrum, moisture absorption and dissolution rate were detected. Then the effects were comprehensively analyzed. Results With the increasing of grinding time, the powder's particle size decreased, morphology and structure tended to be uniform, the specific surface area and porosity increased, the particles assembled easily, the compressibility and the angle of repose increased, the dissolution rate increased dramatically, and there were no significant changes in the infrared spectrum and moisture absorption. Conclusion As the micromeritic properties and dissolution rate of Zhengfupian are considered, Zhengfupian's ultrafine grinding time should be controlled at about 25 min, particle size d0.9 should be around 100.46 μm.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81403115);四川省重大产业技术创新专项项目(2011ZY00299)