目的 研究华南忍冬Lonicera confusa干燥花蕾(山银花)的化学成分。方法 利用反复硅胶柱色谱, Sephadex LH-20、中压柱色谱及半制备液相色谱等方法分离纯化;通过核磁共振谱、质谱等光谱数据鉴定化合物结构。结果 分离得到10个化合物, 分别鉴定为绿原酸(1)、槲皮素(2)、木犀草素(3)、木犀草素-3'-O-α-L-鼠李糖苷(4)、芹菜素-7-O-α-L-鼠李糖苷(5)、反式桂皮酸(6)、对羟基苯甲醛(7)、2,5-二羟基苯甲酸-5-O-β-D-吡喃葡萄糖苷(8)、苄基-β-D-吡喃葡萄糖苷(9)、脱落酸(10)。结论 化合物4～10首次从山银花中分离得到。

Objective To investigate the chemical constituents in the flower buds of Lonicera confusa. Methods The chemical constituents were isolated by repeated silica gel chromatography, Sephadex LH-20, medium pressure column chromatography, and semi-preparative HPLC, and their structures were elucidated by spectroscopic analyses and comparison of NMR data with those reported in literature. Results Ten compounds were isolated and identified to be chlorogenic acid (1), quercetin (2), luteolin (3), luteolin-3'-O-α-L-rhamnopyranoside (4), apigenin-7-O-α-L-rhamnopyranoside (5), trans-cinnamic acid (6), p-hydroxy benzaldehyde (7), gentisic acid-5-O-β-D-glucopyranoside (8), benzyl-β-D-glucoside (9), and abscisic acid (10). Conclusion Compounds 4—10 are obtained from this plant for the first time.

科技部重大新药创制:现代中药创新集群与数字制药技术平台(2013ZX09402203)