目的 探究陶瓷膜微滤决明子Cassia Semen水提液影响膜通量(J)和膜污染阻力(R_f)的因素。方法 以决明子水提液为研究对象, 在单因素试验的基础上, 采用正交设计, 以R_f和J的综合加权评分为评价指标, 优化无机陶瓷膜微滤过程的最佳工艺参数;并对膜微滤过程中4个主要工艺参数与R_f和J的相关性进行分析。结果 最佳膜微滤工艺条件:无机陶瓷膜孔径为0.2 μm、料液质量浓度50.0 g/L、跨膜压差0.1 MPa、膜面流速3.32 m/s;微滤膜孔径对R_f和J的影响具有显著性。结论 工艺条件对决明子水提液膜微滤过程中的J和R_f具有重要的影响;4种工艺参数对膜微滤过程R_f与J的影响主次顺序为膜孔径 > 跨膜压差 > 料液质量浓度 > 膜面流速。

Objective To study the influencing factors of membrane flux (J) and membrane fouling resistance (R_f) in the mincrofiltration of the water extract of Cassia Semen with ceramic membrane. Methods Based on single-factor experiment, the process parameters in the mincrofiltration of the water extract of Cassia Semen were optimized by orthogonal design method using weighted composite score of R_f and J as evaluation. The correlation between R_f and J with main four process parameters was analyzed. Results The best microfiltration process condition was as follow: Membrane aperture size was 0.2 μm, concentration of the water extract of Cassia Semen was 50.0 g/L, transmembrane differential pressure was 0.1 MPa, and crossflow velocity was 3.32 m/s. Membrane aperture size had a significant correlation with R_f and J. Conclusion The process parameters have an important effect on R_f and J. The primary and secondary order of the effect of four process parameters on R_f and J is as follow: Membrane aperture size > transmembrane pressure > feed concentration > crossflow velocity.

国家"十二五"重大新药创制科技重大专项(2011ZX09401-308-307);陕西省重点科技创新团队(2012KTC-20)