[关键词]
[摘要]
目的 研究荚果蕨Matteuccia struthiopteris地上部分的化学成分。方法 采用Diaion HP20、硅胶、ODS、Sephadex LH-20柱色谱以及制备高效液相色谱等多种色谱学方法进行分离纯化, 并根据理化性质和现代波谱学技术鉴定化合物的结构。结果 从荚果蕨地上部分60%乙醇提取物中分离并鉴定12个化合物, 其中10个为megastigmane型降倍半萜类化合物, 分别鉴定为4,7-megastigmadiene-3,9-diol(1)、blumenol A(2)、去氢催吐萝芙木醇(3)、bridelionol F(4)、bridelionol B(5)、3,5,6-trihydroxy-7-megastigmen-9-one(6)、5β,6α-dihydroxy-3β-(β-D-glucoyranosyloxy)-7-megastigmen-9-one(7)、byzantionoside A(8)、dearabinosyl pneumonanthoside(9)、3-hydroxy-β-damascone glucoside(10), 另外2个为倍半萜类化合物, 分别鉴定为反枝苋苷IV(11)、icariside C3(12)。结论 化合物1~12均为首次从荚果蕨属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents in 60% ethanol extract from the aerial parts of Matteuccia struthiopteris. Methods Diaion HP20 macroporous adsorption resin column chromatography (CC), silica gel CC, ODS CC, Sephadex LH-20 CC, and PHPLC were used for the isolation and purification. Structures were identified on the basis of chemical evidences and spectroscopic analyses. Results Twelve compounds were isolated and identified as 4,7-megastigmadiene-3,9-diol (1), blumenol A (2), dehydrovomifoliol (3), bridelionol F (4), bridelionol B (5), 3,5,6-trihydroxy-7-megastigmen-9-one (6), 5β,6α-dihydroxy-3β-(β-D- glucoyranosyloxy)-7-megastigmen-9-one (7), byzantionoside A (8), dearabinosyl pneumonanthoside (9), 3-hydroxy-β-damascone glucoside (10), amarantholidoside IV (11), and icariside C3 (12). Conclusion Compounds 1—12 are reported from the plants of Matteuccia Todaro for the first time.
[中图分类号]
[基金项目]
天然药物活性物质与功能国家重点实验室开放课题基金(GTZK201304)