[关键词]
[摘要]
目的 通过对牛蒡子Arctii Fructus中提取分离牛蒡子苷元产业化过程中的技术难点进行攻关研究, 为牛蒡子苷元的产业化提供一种切实可行的制备工艺, 以促进牛蒡子苷元的产业化发展。方法 采用酸解醇提法得到干膏, 用醋酸乙酯提取, 分得粗品, 对粗品进行乙醇结晶, 得高质量分数牛蒡子苷元。结果 经简单提取分离可得到质量分数 > 75.0%的牛蒡子苷元粗品, 再经乙醇结晶, 即可得到质量分数 > 99.0%的牛蒡子苷元成品。结论 本研究得到一种适合牛蒡子苷元工业化生产的制备工艺。
[Key word]
[Abstract]
Objective To study the difficult extraction technology of Arctii Fructus in separation of arctigenin industrialization, which provides a practical preparation technology suitable for arctigenin industrialization in order to promote the industrialization development of arctigenin. Methods Arctii Fructus was hydrolyzed by acid hydrolysis and alcohol extraction. Then the crude product was separated by ethyl acetate extraction. Finally the pure product of arctigenin was obtained through ethanol crystallization. Results We obtained the crude product which the purity was more than 75.0% by simple extraction and separation. The finished product was crystallized with anhydrous ethanol until the purity of arctigenin is more than 99.0%. Conclusion This study obtains a suitable process for arctigenin industrialization preparation.
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[基金项目]
国家科技部"973"项目课题(2012CB724001)