[关键词]
[摘要]
中药治疗过敏性疾病临床疗效确切, 但其活性成分和作用机制尚在探索中。总结了近年来中药复方、单味中药提取物和中药活性成分在治疗过敏性疾病方面的药理作用研究进展, 突出体现了中药抗过敏作用具有多成分、多靶点和多途径特征, 从而加深对中药抗过敏作用的认识, 一方面为中药治疗过敏性疾病的临床应用提供参考, 另一方面为研发抗过敏中药产品提供信息。
[Key word]
[Abstract]
Clinical evidences demonstrated the effects of Chinese materia medica (CMM) on allergic diseases. However, the bioactive components in CMM and their mechanims of actions remain unkown. The progress of pharmacological studies on the anti-alleric effects of multi-herb formulation, herbal extracts/fraction, and pure compounds of CMM was summerized, which showed the characteristics of multi-component, multi-target, and multi-mechanism of CMM effects. This review provides the information for clinical use of anti-allergic CMM and drug discovery of anti-allergic CMM products.
[中图分类号]
[基金项目]
国家科技重大专项(2013ZX09201020);天津市应用基础及前沿技术研究计划项目(12JCYBJC32400);科技部国家国际合作专项(2013DFA31620)