[关键词]
[摘要]
目的 研究短管兔耳草Lagotis brevituba全草的化学成分。方法 利用溶剂萃取、反复硅胶柱、制备液相色谱等方法分离纯化, 根据理化性质及核磁数据鉴定化合物结构。结果 从短管兔耳草醋酸乙酯和正丁醇部位分离得到11个化合物, 分别鉴定为arvenin I(1)、3,4-二羟基苯乙醇(2)、邻苯二甲酸二(2-乙基)己酯(3)、大车前苷(4)、甘露醇(5)、没食子酸乙酯(6)、原儿茶酸乙酯(7)、邻苯二甲酸二丁酯(8)、β-谷甾醇(9)、毛蕊花糖苷(10)、玉叶金花苷酸(11)。结论 化合物1~3、6、7为首次从兔耳草属植物中分离得到, 4、5为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from Lagotis brevituba. Methods The chemical constituents were isolated by solvent extraction, repeated silica gel chromatography, and preparative-HPLC. Their structures were elucidated by physicochemical properties and NMR data. Results Eleven compounds were isolated from the ethyl acetate and n-butanol fraction of L. brevituba and their structures were identified as arvenin I (1), 3,4-dihydroxyphenylethanol (2), bis (2-ethylhexyl) phthalate (3), plantamajoside (4), mannitol (5), ethyl gallate (6), ethyl 3,4-dihydroxybenzoate (7), dibutyl phthalate (8), β-sitosterol (9), acteoside (10), and mussaenosidic acid (11). Conclusion Compounds 1—3, 6, and 7 are obtained from the plants in Lagotis Gaertn. for the first time. Compounds 4 and 5 are isolated from L. brevituba for the first time.
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[基金项目]
中国科学院重点部署项目(KSZD-EW-Z-004)