目的 研究锦灯笼Physalis alkekengi var. franchetii干燥宿萼的化学成分.方法 采用硅胶、Sephadex LH-20、ODS柱色谱法进行分离纯化,并根据化合物理化性质和MS、NMR等波谱数据鉴定其化学结构.结果 从锦灯笼干燥宿萼85%乙醇提取部位分离得到11个化合物,分别鉴定为4,7-二脱氢新酸浆苦素B(1)、4'-甲氧基山柰酚(2)、酸浆苦素O(3)、25,27-二氢-4,7-二脱氢-7-去氧新酸浆苦素A(4)、酸浆苦素G(5)、对香豆酸(6)、酸浆苦素E(7)、4,7-二脱氢酸浆苦素B(8)、酸浆苦素D(9)、6,6',7,7'-四羟基-5,5'-双香豆素(10)、木犀草素-7-O-α-D-葡萄糖苷(11).结论 化合物10和11为首次从茄科中分离得到,化合物6为首次从酸浆属中分离得到,化合物2和8为首次从该植物中分离得到.

Objective To investigate the chemical constituents in the ethyl acetate extract from Physalis alkekengi var. franchetii. Methods The chemical constituents were isolated by silica gel, Sephadex LH-20, and ODS column chromatographies. Their structures were elucidated on the basis of physicochemical properties and spectral data. Results These compounds were identified as 4,7-didehydroneophysalin B (1), 4'-methoxy kaemferol (2), physalin O (3), 25,27-dihydro-4,7-didehydro-7-deoxyneophysalin A (4), physalin G (5), p-couramic acid (6), physalin E (7), 4,7-didehydrophysalin B (8), physalin D (9), 6,6',7,7'-tetrahydroxy-5,5'- bicoumarin (10), and luteolin-7-O-α-D-glueopyranosid (11). Conclusion Compounds 10 and 11 are isolated from the plants in family Solanaceae for the first time. Compound 6 is firstly reported from the plants of Physalis L., and compounds 2 and 8 are obtained from this species for the first time.