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[摘要]
目的 观察复方苦参注射液治疗鼻咽癌放射性口腔黏膜损伤疗效,并探讨其安全性。方法 选择本院于2011年6月—2014年4月收治的鼻咽癌患者120例作为研究对象,均经放射治疗,随机分为两组,每组60例,对照组于放疗第2周开始应用生理盐水、利多卡因、地塞米松配制的含漱液漱口,观察组于对照组基础上于放疗当日使用复方苦参注射液治疗,3周为1个疗程,连续2个疗程,比较两组疗效差异。结果 观察组放疗后黏膜损伤I、II、III、IV、V级发生例数(占比)分别为27例(45.0%)、19例(31.7%)、9例(15.0%)、5例(8.3%)、0例(0.0%),黏膜损伤情况显著轻于对照组(P < 0.05)。且观察组疼痛程度显著轻于对照组(P < 0.05),两组不良反应发生率比较无明显统计学差异(P > 0.05)。结论 复方苦参注射液治疗鼻咽癌放射性口腔黏膜损伤疗效较佳,可有效缓解疼痛,且临床应用安全。
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[Abstract]
Objective To observe the effect of Compound Sophorae Injection on the treatment of radioactive oral mucosa injury with nasopharyngeal carcinoma, and discuss its security. Methods One hundred and twenty cases of nasopharyngeal carcinoma patients treated in the hospital from June 2011 to April 2014 were selected as the research object, they were treated by radiotherapy treatment and were randomly divided into two groups with 60 cases in each group, the patients in the control group began to be treated with the gargle composed of physiological saline, lidocaine, and dexamethasone in the second week after radiotherapy: The patients in the observation group adopted Compound Sophorae Injection therapy based on the control group with continuous 2 course, then to compare efficacy between the two groups. Results The mucosal injury in grade I, grade II, grade III, grade IV, and grade V after the radiotherapy occurred in the observation group were 27 cases (45.0%), 19 cases (31.7%), 9 cases (15.0%), 5 cases (8.3%), and 0 cases (0.0%), respectively. The mucosal injury of the patients in the observation group was significantly lower than that of the patients in control group (P < 0.05). Pain of the patients in the observation group was significantly lighter than that of the patients in the control group (P < 0.05). Adverse reactions in the two groups had no significant statistical difference (P > 0.05). Conclusion Compound Sophorae Injection used in the treatment of radioactive oral mucosa injury with nasopharyngeal carcinoma has better curative effect and can effectively remove pain with the safety application.
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