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[摘要]
目的 研究新樟Neocinnamomum delavayi茎的化学成分。方法 采用硅胶、MCI、RP-18、Sephadex LH-20凝胶和半制备HPLC等柱色谱方法进行分离纯化,通过波谱分析鉴定化合物的结构。结果 从新樟茎80%乙醇提取物中分离得到17个化合物,包括4个酚苷、3个木脂素、6个倍半萜、3个黄酮以及1个甾醇类化合物,分别鉴定为6-O-紫丁香酰基-1-O-香草酰基-β-D-吡喃葡萄糖苷(1)、6-O-乙酰基-1-O-(3,4,5-三甲氧基苯基)-β-D-吡喃葡萄糖苷(2)、1,6-二-O-紫丁香酰基-β-D-吡喃葡萄糖苷(3)、3,4,5-三甲氧基苯基-6-O-紫丁香酰基-β-D-吡喃葡萄糖苷(4)、鹅掌揪树脂酚B二甲醚(5)、sesartemin(6)、(+)-9'-O-(E)-阿魏酰基-5,5'-二甲氧基落叶松脂醇(7)、oplodiol(8)、柳杉二醇(9)、4-表柳杉二醇(10)、7α,11-二羟基-10(14)-杜松烯(11)、(-)-2,9-丁香烷二醇(12)、菜豆酸(13)、儿茶素(14)、表儿茶素(15)、反式-二氢槲皮素(16)、(24S)-24-乙基胆甾-3β,5α,6β-三醇(17)。结论 化合物1、2为新的酚苷类化合物,分别命名为新樟苷A和新樟苷B,化合物3~17为首次从新樟属植物中分离得到。
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[Abstract]
Objective To investigate the chemical constituents in the stems of Neocinnamomum delavayi. Methods The compounds were isolated by silica gel, MCI gel, RP-18, Sephadex LH-20 column chromatographies and semi-preparative HPLC, and the structures were elucidated by spectroscopic analysis. Results Seventeen compounds were isolated from the 80% EtOH extract in the stems of N. delavayi, including four phenolic glucosides, three lignans, six sesquiterpenoids, three flavonoids, and one sterol. They were identified as 6-O-syringoyl-1-O-vanilloyl-β-D-glucopyranoside (1), 6-O-acetyl-1-O-(3,4,5-trimethoxyphenyl)-β-D-glucopyra- noside (2), 1,6-di-O-syringoyl-β-D-glucopyranoside (3), 3,4,5-trimethoxyphenyl-6-O-syringoyl-β-D-glucopyranoside (4), lirioresinol B dimethyl ether (5), sesartemin (6), (+)-9'-O-(E)-feruloyl-5,5'-dimethoxylariciresinol (7), oplodiol (8), cryptomeridiol (9), 4-epicryptomeridiol (10), 7α,11-dihydroxy-cadin-10(14)-ene (11), (-)-clovane-2,9-diol (12), phaseic acid (13), catechin (14), epicatechin (15), trans-dihydroquercetin (16), and (24S)-24-ethylcholsta-3β,5α,6β-triol (17). Conclusion Compounds 1 and 2 are two new phenolic glucosides named neocinnamosides A and B, respectively, while compounds 3—17 are isolated from the plants of genus Neocinnamomum Liou for the first time.
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