桑叶作为我国传统的常用药食两用中药品种之一,其在治疗糖尿病及其并发症方面的研究与应用日益受到关注和重视。随着桑叶基础研究不断深入及产业化开发的发展,其防治糖尿病及其并发症的效应成分群与作用机制不断被揭示。在前期研究基础上,通过对近年来国内外学者在糖尿病发病机制的认识、桑叶对其调节血糖的功效成分及其作用机制等方面进行归纳与分析。桑叶生物碱类成分是桑叶中调节血糖最为显著和明确的一类资源性化学成分;其次是桑叶黄酮类成分具有一定的调节血糖的作用;而桑叶多糖类成分则间接地起到降血糖作用。以期为桑叶调控血糖及防治糖尿病并发症的作用机制深入研究提供指引,为桑叶资源的开发利用提供依据和参考。

Mori Folium (mulberry leaves or the leaves of Morus alba) as one of Chinese materia medica and food raw materials, its research and application in the treatment of diabetes and diabetic complications have become an increasing concern to the majority of scientists. With deepening the basic research and industrial development of Mori Folium, the bioactive component groups and their action mechanisms of Mori Folium used for the prevention and treatment of diabetes and diabetic complication continue to be revealed. In this paper, based on the previous research, we summarize and analyze the understanding of domestic and foreign scholars about the pathogenesis of diabetes and the active component groups and their action mechanisms of Mori Folium for the prevention and treatment of diabetes and diabetic complication in recent years in order to provide the guidance for the further study and the reference for the development and utilization of Mori Folium resource.

国家自然科学基金资助项目(81373889,30973885);教育部新世纪优秀人才支持计划项目(NCET-13-0873)