目的 应用信息熵理论优选热毒宁口服制剂中金银花与栀子的提取工艺。方法 以绿原酸、栀子苷、木犀草苷提取率及浸膏得率为综合评价指标,选取提取时间、加水量及提取次数为影响因素,采用信息熵赋权法确定各指标的客观权重,实现对提取工艺的正交试验优选。结果 最佳提取工艺为12倍量水提取3次,每次1 h。结论 信息熵理论可用于热毒宁口服制剂中金银花与栀子提取工艺的优选。

Objective To optimize the extraction technology for Lonicerae Flos and Gardeniae Fructus in Reduning Oral Preparation by information entropy theory. Methods With the contents of chlorogenic acid, gardenoside, luteoloside, and the yield of extract as comprehensive evaluation indexes, the extraction time, dosage of water, and extraction times were selected as factors, the weight of them was determined by information entropy theory, and the extraction technology was optimized by orthogonal test. Results Optimum extraction technology was: Reflux extraction for 3 times with 12 folds water, 1 h each time. Conclusion The information entropy theory could be used in optimizing the extraction technology for Reduning Oral Preparation.

科学技术部国家重大新药创制项目(2013ZX09402203):现代中药创新集群与数字制药技术平台