[关键词]
[摘要]
目的 制备三七接骨凝胶膏剂并对其体外透皮特性进行研究。方法 在单因素考察的基础上,利用中心复合设计-效应面法,以外观性状、初黏力、持黏力、剥离强度为指标优化三七接骨凝胶膏剂最佳基质处方,并采用Franz扩散池法,以川续断皂苷VI、人参皂苷Rg1、人参皂苷Rb1、三七皂苷R1为指标成分,对其进行体外透皮研究。结果 凝胶膏剂最佳处方为ViscomateTM NP700-卡波姆940-PVPK90-高岭土-甘羟铝(1.86:1.48:0.49:0.5:0.16);24 h内川续断皂苷VI、人参皂苷Rg1、人参皂苷Rb1、三七皂苷R1的体外透皮速率依次为1.868、4.233、1.149、1.558 μg/(cm2·h)。结论 三七接骨凝胶膏剂具有较好的释药性和透皮性,透皮行为符合零级动力学过程。
[Key word]
[Abstract]
Objective To prepare Sanqi Hydrogel Patch used for setting a bone and study its transdermal permeation properties in vitro. Methods In this paper, the appearance description, initial bonding strength, endurance bonding strength, and peel strength were taken as indexes. Based on the result of a single factor experiment, the formula for the Sanqi Hydrogel Patch was optimized by central composite design-response surface methodology. Franz diffusing cells method was chosen to study its transdermal permeability in vitro with asperosaponin VI, ginsenoside Rg1, ginsenoside Rb1, and notoginsenoside R1 as index components. Results The optimal ratio of the prescription was as follows: ViscomateTM NP700-Carbomer 940-PVPK90-kaoline-dihydroxyaluminum aminoacetate (1.86:1.48:0.49:0.5:0.16). Within 24 h, the transdermal rates of asperosaponin VI, ginsenoside Rg1, ginsenoside Rb1, and notoginsenoside R1 were 1.868, 4.233, 1.149, and 1.558 μg/(cm2·h). Conclusion Sanqi Hydrogel Patch has a better release and transdermal properties and the transdermal actions are consistent with zero-order kinetics.
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[基金项目]
重庆市科委应用开发重大项目(cstc2014yykfC10006)