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[摘要]
目的 研究石竹科植物瞿麦Dianthus superbus全草的化学成分。方法 利用硅胶柱、Sephadex LH-20凝胶柱和HPLC等色谱手段进行分离纯化,通过NMR、MS等光谱手段进行结构鉴定。结果 从瞿麦全草石油醚萃取部位中分离得到9个化合物,分别鉴定为5-羟基-7,3',4'-三甲氧基二氢黄酮(1)、5,3'-二羟基-7,4'-二甲氧基二氢黄酮(2)、5,4'-二羟基-7,3'-二甲氧基二氢黄酮(3)、β-菠甾醇(4)、胖大海素A(5)、(24R)-环阿屯-25-烯-3β,24-二醇(6)、(24S)-环阿屯-25-烯-3β,24-二醇(7)、豆甾-7-烯-3β-醇(8)和羟基二氢博伏内酯(9)。结论 化合物1~9均为首次从瞿麦中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents of Dianthus superbus. Methods The chemical constituents were isolated from 95% alcohol extract of D. superbus by silica gel column chromatography, Sephadex LH-20 column chromatography, and HPLC. Their chemical structures were elucidated on the basis of 1D NMR and ESI-MS spectroscopic analyses. Results Nine compounds including three flavanoids, two sterols, three triterpenes, and one γ-lactone were isolated. Their structures were identified as 5-hydroxy-7,3',4'-trimethoxyflavanone (1), 5,3'-dihydroxy-7,4'-dimethoxyflavanone (2), 5,4'-dihydroxy-7,3'-dimethoxyflavanone (3), β-spinasterol (4), sterculin A (5), (24R)-cycloart-25-ene-3β,24-diol (6), (24S)-cycloart-25-ene-3β,24-diol (7), stigmast-7-en-3β-ol (8), and hydoxydihydrobovolide (9). Conclusion All the compounds (1—9) are isolated from D. superbu for the first time.
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[基金项目]
国家自然科学基金资助项目(31300283)