目的 研究藏药密生波罗花Incarvillea compacta根的化学成分.方法 采用硅胶柱色谱、Sephadex LH-20、ODS柱色谱及高效液相制备色谱等方法进行分离纯化,根据理化性质及波谱数据确定化合物的结构.结果 从密生波罗花根的95%乙醇提取物中分离得到4个苯乙醇苷类化合物,分别鉴定为Z-3'''-异甲氧基圆齿列当苷(1)、3'''-甲氧基圆齿列当苷(2)、圆齿列当苷(3)和异角胡麻苷(4).结论 化合物1为新化合物;化合物2～4为首次从角蒿属植物中分离得到.

Objective To study the chemical constituents from the roots of Incarvillea compacta (Tibetan medicine). Methods The constituents were isolated and purified by silica gel, Sephadex LH-20, ODS column chromatography, and preparative HPLC. Their structures were elucidated on the basis of their physicochemical properties and spectral data. Results Four phenylethanoid glycosides were obtained from the ethanol extract in the roots of I. compacta and identified as Z-3'''-O-methylisocrenatoside (1), 3'''-O-methylcrenatoside (2), crenatoside (3), and isomartynoside (4), respectively. Conclusion Compound 1 is a new phenylethanoid glycoside and compounds 2-4 are isolated from the plants of Incarvillea A. Juss. for the first time.

"重大新药创制"科技重大专项"十二五"计划(综合性新药研究开发技术大平台)(2012ZX09301-002-001-026);药植所创新团队发展计划资助