[关键词]
[摘要]
目的 研究金黄凝胶的成型工艺.方法 以凝胶剂的成型性、稳定性、失水率、pH值为指标,从凝胶基质、保湿剂、黏合剂用量等方面进行成型工艺考察.结果 优选成型工艺为卡波姆1 g静置溶胀4 h,加入甘油10 g、药粉4 g,搅匀后加入三乙醇胺1 g,加水至100 g,搅匀即得.结论 本方法为凝胶剂的研究提供评价标准,同时为进一步优化金黄凝胶成型工艺提供了基础.
[Key word]
[Abstract]
Objective To study the preparation process of golden gel. Methods Taking the gel forming properties, stability, water loss rate, and pH value as investigation indexes, the influences of gel matrix, humectants, and binder dosage on gel forming were studied by single factor experiments. Results The optimal conditions of preparation process were as follows: 1 g carbopol static swelling for 4 h, adding 10 g glycerol and 4 g drug powder, stirring after adding 1 g triethanolamine, adding water to 100 g, stirring well to obtain the gel. Conclusion The method provides the evaluation criterion and basis for the further optimization of the golden gel forming process.
[中图分类号]
[基金项目]
科技部重大新药创制--现代中药创新集群与数字制药技术平台(2013ZX09402203)