[关键词]
[摘要]
目的 研究锡叶藤Tetracera asiatica地上部分的化学成分.方法 采用正、反相硅胶柱色谱,凝胶Sephadex LH-20色谱以及HPLC等多种技术进行分离纯化,并通过理化性质及波谱数据鉴定化合物结构.结果 从锡叶藤地上部分95%乙醇提取物中分离得到12个化合物,分别鉴定为鼠李柠檬素(1)、异鼠李素(2)、柚皮素(3)、鼠李素(4)、山柰酚(5)、(+)-紫杉叶素(6)、槲皮素(7)、银锻苷(8)、槲皮素-3-O-α-L-鼠李糖苷(9)、(-)-表儿茶素-3-(3-O-甲基)-没食子酸酯(10)、表儿茶素-3-O-没食子酸酯(11)、(-)-表儿茶素(12).结论 化合物1~12均为首次从该植物中分离得到.
[Key word]
[Abstract]
Objective To study the chemical constituents in the aerial parts of Tetracera asiatica. Methods Silica gel, ODS, Sephadex LH-20 gel column chromatographies, and HPLC were used to isolate and purify the compounds. And the structures of the obtained compounds were identified by their physical properties and spectroscopic data. Results Twelve compounds were separated and purified from the alcoholic extract of T. asiatica. They were identified to be rhamnocitrin (1), isorhamnetin (2), naringenin (3), rhamnetin (4), kaempferol (5), taxifolin (6), quercetin (7), tiliroside (8), quercetin-3-O-α-L-rhamnopyranoside (9), (-)-epicatechin 3-(3-O-methyl) gallate (10), epicatechin-3-O-gallate (11), and (-)-epicatechin (12). Conclusion Compounds 1-12 are obtained from this plant for the first time.
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[基金项目]
科技部课题"重大新药创制"科技重大专项公共资源平台课题"面向新药发现的数字化中药化学成分库"(2011ZX09307-002-01)