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[摘要]
目的 研究甘草Glycyrrhiza uralensis废渣的化学成分.方法 采用硅胶吸附柱色谱、Sephadex LH-20柱色谱、高效液相色谱等分离手段进行分离纯化,根据化合物的理化性质和波谱数据鉴定化合物的结构.结果 从新疆产甘草废渣75%乙醇提取物中分离得到了5个化合物,分别鉴定为槐香豆素C(1)、3β-O-对羟基-反-肉桂酰-齐墩果酸(2)、3-羰基甘草次酸(3)、3β,18-O-异丙叉-8(14),15-异右松脂烷二烯(4)、3β,18-O-异丙叉-7,15-异右松脂烷二烯(5).结论 化合物1为新的香豆素类化合物,命名为槐香豆素C;化合物2、4、5为首次从该属植物中分离得到.
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[Abstract]
Objective To study the chemical constituents from the residue of Glycyrrhiza uralensis. Methods Five compounds were separated and purified by silica gel, Sephadex LH-20, and preparative HPLC. The structures were identified by physicochemical properties and spectral analyses. Results Five compounds were obtained from 75% ethanol extract of G. uralensis residue and identified as sophoracoumestan C (1), 3β-O-(p-hydroxy-(E)-cinnamoyl)-1-oleanen-28-oic acid (2), 3-oxo-glycyrrhetinic acid (3), sandaracopimaradiene-3β,18-diol acetonide (4), and isopimaradiene-3β,18-diol acetonide (5). Conclusion Compound 1 is a new coumarin named sophoracoumestan C. Compounds 2, 4, and 5 are obtained from the plants of Glycyrrhiza Linn. for the first time.
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[基金项目]
辽宁省天然药物活性成分工业化色谱制备公共服务平台(2011412004-7)