[关键词]
[摘要]
目的 研究瑶药石柑子Pothos chinensis全草的化学成分.方法 应用各种柱色谱及制备液相色谱等分离方法进行分离纯化,根据化合物的理化性质和波谱数据进行结构鉴定.结果 从石柑子全草甲醇提取物中共分离得到17个化合物,分别鉴定为N-反式桂皮酸酰对羟基苯乙胺(1)、N-反式香豆酰酪胺(2)、N-顺式香豆酰酪胺(3)、N-反式阿魏酸酰对羟基苯乙胺(4)、N-顺式阿魏酸酰对羟基苯乙胺(5)、黑麦草内酯(6)、去氢催吐萝芙木醇(7)、(3S, 5R, 8R, 9R)-5, 8- epoxy-6-megastigmene-3, 9-diol(8)、(3R, 6R, 7E)-3-hydroxy-4, 7-megastigmadien-9-one(9)、(3R)-4-[(2R, 4S)-2-hydroxy-2, 6, 6-trimethyl-cyclohexylidene]-3-buten-2-oneiol(10)、7-甲氧基香豆素(11)、欧前胡素(12)、7-羟基-8-甲氧基香豆素(13)、6-羟基-7-甲氧基香豆素(14)、吲哚-3-醛(15)、(-)-杜仲树脂酚(16)和大豆苷元(17).结论 所有化合物均为首次从该属植物中分离得到.
[Key word]
[Abstract]
Objective To investigate the chemical constituents in the whole herbs of Pothos chinensis. Methods The chemical constituents were isolated and purified by various column chromatographic methods and preparative HPLC. Their structures were identified by physicochemical properties and spectral analyses. Results Seventeen compounds were isolated from the methanol extract and identified as N-trans-cinnamoyltyramine (1), N-trans-p-coumaroyltyramine (2), N-cis-p-coumaroyltyramine (3), N-trans-feruloyltyramine (4), N-cis-feruloyltyramine (5), loliolide (6), dehydrovomifoliol (7), (3S, 5R, 8R, 9R)-5, 8-epoxy-6-megastigmene-3, 9-diol (8), (3R, 6R, 7E)-3-hydroxy-4, 7-megastigmadien-9-one (9), (3R)-4-[(2R, 4S)-2-hydroxy-2, 6, 6-trimethylcyclohexylidene]-3- buten-2-oneiol (10), 7-methoxycoumarine (11), imperatorin (12), 7-hydroxy-8-methoxycoumarin (13), 6-hydroxy-7-methoxycoumarin (14), indole-3-aldehyde (15), (-)-medioresinol (16), and daidzein (17). Conclusion All the compounds are isolated from the plants in Pothos L. for the first time.
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[基金项目]
中医药行业科研专项(201207002);中医药公共卫生专项(财社 [2011]76号,财社 [2012]13号)