[关键词]
[摘要]
目的 研究苏木Caesalpinia sappan种子的化学成分。方法 采用柱色谱技术对苏木种子的95%甲醇提取物进行分离纯化,采用波谱技术结合化学方法进行结构鉴定。结果 从苏木种子提取物中分离得到了15个化合物,包括13个卡山烷型二萜类化合物,分别鉴定为caesaldekarin K(1)、demethylcaesaldekarin C(2)、taepeenin H(3)、taepeenin I(4)、caesalpinista A(5)、caesalpinista B(6)、cordylane C(7)、deoxycaesaldekarin C(8)、phanginin A(9)、phanginin B(10)、phanginin C(11)、phanginin D(12)、phanginin E(13)及β-谷甾醇(14)、β-胡萝卜苷(15)。结论 化合物1~8、14~15为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the seeds of Caesalpinia sappan. Methods The constituents were isolated and purified by silica gel chromatography repeatedly, and the structures were identified by spectral analysis and chemical methods. Results Fifteen compounds were isolated from the seeds of C. sappan and the structures were identified as caesaldekarin K (1), demethylcaesaldekarin C (2), taepeenin H (3), taepeenin I (4), caesalpinista A (5), caesalpinista B (6), cordylane C (7), deoxycaesaldekarin C (8), phanginins A—E (9—13), β-sitosterol (14), and β-daucosterol (15). Conclusion Compounds 1—8 and 14—15 are first obtained from the seeds of C. sappan.
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[基金项目]
“重大新药创制”科技重大专项“十二五”计划:综合性新药研究开发技术大平台(2012ZX09301-003)