目的 分析不同加工方法对太子参Pseudostellariae Radix中化学成分的影响。方法 采用UPLC-Triple TOF-MS/MS技术对20批样品进行测定，通过多级串联质谱分析，结合Mass数据、软件数据库及相关文献对总离子流图主要分子离子峰进行归属，数据处理用SIMCA-P软件进行多元统计分析。结果 鉴定出11种化合物；主成分得分图显示，不同加工方法太子参样品间的差异得到明显区分，通过载荷图筛选出差异显著的11种标志物，且这11种标志物呈现出不同的变化规律。结论 为揭示不同加工方法对太子参代谢产物差异性的影响规律提供科学依据。

Objective To analyze the changes of chemical composition of Pseudostellariae Radix using different processing methods. Methods To determine 20 batches of samples by UPLC-Triple TOF-MS/MS and tandem mass spectrometry and by combining Mass data, database, and related software for total ion current literature major molecular ion peaks attributable. Data processing was carried out using SIMCA-P software to study multivariate statistical analysis. Results Thirteen compounds were identified, and the differences of PCA between samples of Pseudostellariae Radix using different processing methods were distinguishable, and 11 kinds of markers were picked from loading chart by significant differences. The 11 kinds of markers presented different changing laws. Conclusion The research provides experimental data for revealing the laws of different processing methods on metabolites of Pseudostellariae Radix.

国家自然科学基金项目（81274016）;国家科技支撑计划项目（2011BAI13B04）;江苏高校优势学科建设工程资助项目（ysxk-2014）