[关键词]
[摘要]
目的 研究绞股蓝Gynostemma pentaphyllum 全草的化学成分。方法 采用硅胶、聚酰胺、Sephadex LH-20等色谱法进行分离纯化,通过理化性质和波谱分析鉴定化合物的结构。结果 从绞股蓝全草中分离得到17个化合物,分别鉴定为月桂酸(1 )、β-谷甾醇(2 )、3, 5, 3'-三羟基-4', 7-二甲氧基二氢黄酮(3 )、邻二苯酚(4 )、3'-O-甲基花旗松素(5 )、槲皮素(6 )、鼠李素(7 )、α-菠菜甾醇-3-O-β-D-吡喃葡萄糖苷(8 )、3, 4-二羟基苯甲酸(9 )、异鼠李素-3-O-β-D-芸香糖苷(10 )、鼠李糖(11 )、丙二酸(12 )、β-乙氧基芸香糖苷(13 )、芦丁(14 )、商陆苷(15 )、人参皂苷Rb1(16 )、胡萝卜苷(17 )。结论 化合物1、3~5、7、9、10、12 为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Gynostema pentaphyllum. Methods The chemical constituents were isolated and purified by silica gel, polyamide, and Sephadex LH-20 chromatography. Their structures were elucidated by physicochemical properties and spectral analysis. Results Seventeen compounds were isolated and identified as dodecanoic acid (1 ), β-sitosterol (2 ), 3, 3', 5-trihydroxy-4', 7-dimethoxyflavanone (3 ), 1-2-benzenediol (4 ), 3'-O>-methyltaxifolin (5 ), quercetin (6 ), rhamnetin (7 ), α-spinasterol-3-O>-β-D-glucopyranoside (8 ), 3, 4-dihydroxy benzoic acid (9 ), narcissoside (10 ), L-rhamnosemono-hydrate (11 ), malonic acid (12 ), β-ethoxy-rutinoside (13 ), rutin (14 ), ombuoside (15 ), ginsenoside Rb1 (16 ), and β-daucosterol (17 ). Conclusion Compound 1, 3—5, 7, 9, 10 , and 12 are obtained from G. pentaphyllum for the first time.
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[基金项目]
广西自然科学基金重点项目(2010GXNSFD013050)